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KMID : 1094020150320020191
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Journal of Veterinary Clinics
2015 Volume.32 No. 2 p.191 ~ p.195
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Community-acquired Extended-spectrum and Plasmid-mediated ampC Beta-lactamase-producing Multidrug-resistant Enterobacter cloacae Septicaemia in a Cat with Euthyroid Sick Syndrome
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Han Jae-Ik
Na Ki-Jeong
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Abstract
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A 7-year-old castrated male Korean Shorthair cat was referred with lethargy and anorexia. Laboratoryexamination revealed moderate degenerative changes of peripheral neutrophils on blood smear examination anddecreased levels of free and total thyroxine (T4) as well as bacterial growth on blood culture. Molecular analyses ofthe 16S ribosomal RNA gene and heat shock protein 60 gene confirmed the bacterium as Enterobacter cloacae. Aminimal inhibitory concentration test showed multidrug resistance of the bacterium against 16 antibiotics. Polymerasechain reaction (PCR) and subsequent sequencing specifically for blaTEM, blaSHV, blaCTX-M, and plasmid-mediated ampCgenes revealed positive results to blaTEM-1, blaCTX-M-15, and plasmid-mediated blaACT-1 genes, indicating that the isolatedbacterium contains plasmids containing genes encoding extended-spectrum beta-lactamase and plasmid-mediated ampCbeta-lactamase. After 1 month of treatment with antibiotics and levothyroxine, the cat’s condition improved; both thethyroid function test and the blood culture showed no abnormalities. This is the first report of community-acquiredmultidrug-resistant E. cloacae-induced euthyroid sick syndrome in a cat. By the prompt diagnostic procedures andproperly selected antibiotic therapy, the cat was recovered from the multidrug-resistant bacterium-induced septicaemia.
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KEYWORD
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cat, septicaemia, Enterobacter cloacae, multidrug resistance, euthyroid sick syndrome
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